# Silence Therapeutics aims at Takeda with new data in rare blood cancer

> **Open Intelligence Dossier** · First detected: 2026-08-10 20:07 UTC · Category: Business

## Executive Summary
Silence Therapeutics advances its gene-silencing drug divesiran toward Phase III following mid-stage trial success in polycythemia vera.

## Intelligence Brief
Recent coverage from STAT, Fierce Biotech, Endpoints News, FirstWord Pharma, OncLive, Cure Today, and Pluang details significant clinical developments regarding Silence Therapeutics and its gene-silencing drug candidate, divesiran. According to these reports, divesiran successfully met its primary response end point in a mid-stage trial focused on polycythemia vera, a rare blood cancer. Specifically, the data indicates that divesiran eliminated the need for phlebotomy in eighty-eight percent of patients suffering from this condition. Silence Therapeutics is now preparing to advance the therapeutic into Phase III trials. Outlets such as STAT and Fierce Biotech emphasize that this mid-stage win positions Silence Therapeutics directly against Takeda in the competitive landscape of rare blood cancer treatments.


Endpoints News spells out the technical success of the gene-silencing mechanism, while FirstWord Pharma outlines the strategic preparation for the upcoming Phase III study. OncLive and Cure Today focus heavily on the clinical specifics, highlighting the primary response end point achievement and the notable reduction in phlebotomy dependency among trial participants. This trend emerges within the broader context of pharmaceutical development in rare diseases, where gene-silencing technologies seek to replace traditional, frequent interventions like therapeutic phlebotomy. Polycythemia vera creates chronic treatment burdens for patients, making the prospect of eliminating phlebotomy an important milestone. Coverage does not yet specify the exact timeline for the initiation of the Phase III trials, nor does it detail potential regulatory submissions or commercial partnership structures beyond the stated competitive positioning against Takeda.


Observers and market participants will be tracking subsequent announcements from Silence Therapeutics regarding the precise design and start date of the Phase III clinical program for divesiran. Further updates from the reporting outlets will likely monitor how Takeda responds to these mid-stage data releases and whether additional clinical findings emerge from the current trial cohort. Coverage does not yet specify any further pipeline adjustments or upcoming investor event dates related to the program.

## Multi-Source Evidence Table
| Source Outlet | Headline | Verification URL |
|---|---|---|
| Pluang | Stocks surge on major acquisition deals and str... | [Source Link](https://news.google.com/rss/articles/CBMilAFBVV95cUxOZlhnVG1JeHM3OXZwcXNpQmZBQXktT05GRERFQlY3TGFnNHhTcU1TUlNjVWNtbHRWVVVGVkNSNGxBVjdoYzMwa0lmQ3lDTGxMODYzNXl1dDNzNUZ0QnhOdmtBWXFhODZsM0Exd2dzSmdJT1YzemRzaXRhVzhGeEhaVFlndEZhQ1pkYVYzLWk5UzBlR240?oc=5) |
| Cure Today | Divesiran Eliminates Need for Phlebotomy in 88% of Patients With Polycythemia Vera | [Source Link](https://news.google.com/rss/articles/CBMisgFBVV95cUxPR1h5Y1VrTG4zZnNXSmhRWXBQTDEyUjdoa2UxeHFzNXNZb2laS0RwUFNseTZTOV85VGktT3V6c2hHZFFUbi1Hald3TUxrVkZBckZhYW15N1FIWGhRWk1KWUR4cFQyLW9YTWQtMW1RXzEwRzVlQkMtRmVyYW04dU5oNXdmVTdRQzhNV0VGaFBHTHZqWjZoT0hxV2wzNVVxTFNGcXUtdWVMWHh4aHd4eXRqYmxB?oc=5) |
| FirstWord Pharma | Silence posts mid-stage polycythemia vera win, preps for Phase III | [Source Link](https://news.google.com/rss/articles/CBMiU0FVX3lxTE1YODk4V2xmQVJwZlpFVHM4MWQ3TXlpTFdwaWZiSnpmUS1XdDBCdTBwV0tKSV81TWlYQkxwRm45dzk2SV91dkJRZW16WEZUWlZaWlVV?oc=5) |
| OncLive | Divesiran Meets Primary Response End Point in Phlebotomy-Dependent Polycythemia Vera | [Source Link](https://news.google.com/rss/articles/CBMiswFBVV95cUxPSE1mV09DZGFyYTZQY19vNUNSTHFxS1MtQWNWR01HdUxRS01BLWUtUEtYaFJkM1pIQTluQjFCV3QyUUdzMVFZQXBNYWNEVi1vMFJfMW5vT01uZTAyRkVseWhQVGVyUXVtWUZ1VFhlZnlKY0tuRVNmVUVybDJ2RVFyYWpGcFU3VUwycEhxLXZCYVNSWEJyaGJoVDZTcEZlakhWTkhnZXhxS0FPWW5wYk1NR1g5WQ?oc=5) |
| Endpoints News | Silence spells out Phase 2 success for gene-silencing drug in rare blood cancer | [Source Link](https://news.google.com/rss/articles/CBMipgFBVV95cUxNc1ZsV2lIM3U5bFZaTk9Ndlk0aWJWR2dNbEI4MG5xWjFwc1A3SXVNQWZ2Z2xGdUlnT0ZORDlBN1hPajNKcEE1bGhQXzA3bENKdHVWN1pZQl9TSWFSSTRHTXhpVE0tcEpOdmhhRnM3b3dXX1lhNEt0TDlaNmplSzR6YzczVTRIQjlvcnF0TS1EbzI5RmZ0MlRqVDNxVUJpeV9hRDFNNEJB?oc=5) |
| Fierce Biotech | Silence brings the noise to Takeda with phase 2 blood cancer win | [Source Link](https://news.google.com/rss/articles/CBMilAFBVV95cUxOQXF5akhhMHFHSUVGQUJPM3RCYVdBcVJOSWtQUkg0a09BVWgzaU1tOXVLY3ZhRlduM2taZHFqNUNFZmRnQmxuS2hsbXZOdlhPVkljQzZESjV2OFpkTW1Cd1FVU0h0SFR6bUczRVBtX2pyOW1fYnBnZHJneGl0bFlaV3Z5Wm9ydWw2VGxiREs5amREUmxV?oc=5) |
| STAT | Silence Therapeutics aims at Takeda with new data in rare blood cancer | [Source Link](https://news.google.com/rss/articles/CBMipwFBVV95cUxPdE4tNFB6VWwwUU1TNzBiamoyc3lNcjlvQUhBR0lLQTZoN2RjUW5BbFNubFZudFJQUWFGU1ZpTmQxclBWQW9RZDU3dzdhU3B2c2xOc2dXNUZnM1lKeGRjcWM4NGdoVW4xRjdOSHVzRkJEcmRRalNGYjdpc0RNamRCWnQ1WmFuTXNqd25hZTYybWZ3RGJtMFhGYmRUWHg2Snd2ZGNwWEZPOA?oc=5) |

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*Canonical Source: https://pulse.byoviral.com/trend/2026-08-10/silence-therapeutics-aims-at-takeda-with-new-data-in-rare-blood-cancer*