# Updated: Novo Nordisk cans 2 more trials of IL-6 heart drug for futility

> **Open Intelligence Dossier** · First detected: 2026-09-07 15:07 UTC · Category: Business

## Executive Summary
Novo Nordisk has terminated two additional phase 3 trials of its cardiovascular drug ziltivekimab due to futility, impacting its growth strategy.

## Intelligence Brief
Novo Nordisk has announced the termination of two cardiovascular trials involving ziltivekimab, a drug designed to lower inflammation by targeting IL-6. According to reports from Endpoints News and STAT, these specific studies were stopped early because of futility. This decision comes as part of a broader trend of trial cancellations for the pharmaceutical company, specifically affecting its efforts to expand its therapeutic reach into heart failure and chronic kidney disease. The move indicates that the drug failed to meet the necessary benchmarks to justify the continuation of these particular clinical assessments. Coverage from Reuters and Fierce Biotech emphasizes that these cancellations significantly diminish the company's hopes for its chronic kidney disease program. Reuters specifically highlights that these failed trials dim the prospects for Novo Nordisk's growth beyond its current success in the obesity market.


Firstwordpharma.com further notes that the company's aspirations for ziltivekimab are dwindling as the heart failure studies were stopped prematurely. These outlets collectively frame the event as a setback for a company seeking to diversify its blockbuster portfolio away from weight-loss medications. To understand why this matters, it is necessary to recognize the strategic importance of the IL-6 heart drug in Novo Nordisk's long-term pipeline. The company had positioned ziltivekimab as a potential driver of future revenue, aiming to tackle inflammatory markers associated with heart disease and kidney dysfunction. By attempting to move into the cardiovascular space, the company sought to replicate the commercial success of its obesity treatments. The failure of these phase 3 trials suggests a significant hurdle in the drug's ability to provide the clinical benefit required for regulatory approval and market entry.


Moving forward, the industry will be watching for further updates on the remaining components of Novo Nordisk's CKD and cardiovascular programs. Based on the reporting from Endpoints News and other outlets, the primary focus remains on whether any other trials for ziltivekimab will be maintained or if the entire program will be reconsidered. There is a stated need for the company to find new avenues for growth to sustain its trajectory outside of the obesity sector. Future disclosures will likely clarify the total number of scrapped trials and the resulting impact on the company's overall research and development pipeline.

## Multi-Source Evidence Table
| Source Outlet | Headline | Verification URL |
|---|---|---|
| Fierce Biotech | Novo’s blockbuster hopes for CKD program dwindle after more phase 3 trials scrapped | [Source Link](https://news.google.com/rss/articles/CBMitwFBVV95cUxQbHlHZm5DSEMzYzJ1RE82Tm81eFdRWlhWX1drTTREbHJsek93UWZ0WmptcFQ5dEoya0NKVms3d0RPRks2MDctZmh5T3BYSDZwY3FBNGtBbW9XWDhuRUUtN0hUSl85YW90SXdHMnkyOU1ueDhYd2NJUURMT2d1T0VHRzNzS0JvMnR2NFktaThIb0daS3RYUTZiYk1mVVFwQkdtdlplSDczM21QdU10MFVpaWJqbWwwTGs?oc=5) |
| firstwordpharma.com | Novo's hopes for ziltivekimab dwindle as two heart failure studies stopped early | [Source Link](https://news.google.com/rss/articles/CBMiU0FVX3lxTE5HdlY0TnRsR1VBVkJuUEJzdFZiUGlyYUdDakJZalR6OHJXelZGWERyV1pzd21Wbk83bzM3YVF4Z3RWcmN3dEhTSWtyaW1aem1KSHNZ?oc=5) |
| STAT | Novo Nordisk stops two cardiovascular trials of drug aimed at lowering inflammation | [Source Link](https://news.google.com/rss/articles/CBMikwFBVV95cUxPeEZucDMxYUYxV1plNU93b1RISV9HUTB5Vmh1MFRYRGZKUVVydHRXRTZiOU5IVF9BTkFFNmZJdGd0VmlneFBoMTlsUENrd0VHRldubHFlNWNTV3dlZnptaExQeXBaWkpNVWo1bmNHMi1DZEhRLU4wZTlEczFqS0Y2ZFBzYUJsWVNzUExFS215UmNuUlU?oc=5) |
| Reuters | Novo scraps two more heart drug trials, further dimming growth beyond obesity | [Source Link](https://news.google.com/rss/articles/CBMiyAFBVV95cUxPWmQwbG9VUnlLeWZZV3NJdWtkNzVBaER0RzBNN3Jwa0RPVUZsRzRpUWhwUGVwN24xUUxNV0lSRS1KM3ZXeWs1YU55Z1JrakZFYzJ4NWV3THhlVFdwdHQ5VEI2VFh1cW53R3Rqc2JBMFhBRWVrazlEeTBCaGh2di1xeDB4Qnp3SmdvNWlZeEpyZEkwdUl3a05PandpMzZDcW44MUdQUVdHU041UEc3cGJLT3lRczFMYnYwMEM4UkRqWUlDc2lydFBuTg?oc=5) |
| Endpoints News | Updated: Novo Nordisk cans 2 more trials of IL-6 heart drug for futility | [Source Link](https://news.google.com/rss/articles/CBMikwFBVV95cUxNUWtudm9PVUpJWlNWNVRKNy1NbFhvLXVqNF9jaEVGaU02Q2l3NXZQZUtPdm82dGxXdmRBeW9CM3BaSzdRUlo1dmVuM1VOX25nSG9EQ25ObGVZLVFyUUFkUlNqX29ESEJvYU5VdFphLUQ1ODZYanE0WTY1YnNGWjVzdFUtRFozVWxZQlYxOWl0eC03TU0?oc=5) |

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*Canonical Source: https://pulse.byoviral.com/trend/2026-09-07/updated-novo-nordisk-cans-2-more-trials-of-il-6-heart-drug-for-futility*